|
KMID : 0379120010290010015
|
|
Korean Journal of Mycology
2001 Volume.29 No. 1 p.15 ~ p.21
|
|
|
Immunomodulatory Activities by Difference in Molecular Size of the Proteoglycan Extracted from Ganoderma lueidum IY009
|
|
Kim Kwang-Soo
Lee June-Woo
Chun Uck-Han
Kim Yong-Seok
Baek Seong-Jin
|
|
|
Abstract
|
|
|
|
This study was conducted to investigate the immunomodulatory activities of proteoglycan extracted from cultured mycelia of Ganoderma lucidum IY009. The proteoglycan contained two polymer peaks, one was the higher MW peak of 2,000 kD and the other was low peaks of 12 kD. To understand the part of strong pharmaceutical activity between two peak, the proteoglycan was separated by ultrafiltration and column chromatography and then examined the various pharmaceutical effects. High molecular weight fraction possesing high content of β-finked glucan was exhibited high antitumor activity against sarcoma 180 bearing ICR mouse. And also, anticomplementary activity was highly observed in high molecule fraction than low it fraction. When the raw 264.7 and marine peritoneal macrophage treated with low fraction, high fraction and other stimuli. The activities inducing tumor necrosis factor of the high fractions were 2.2∼2.5 times stronger than that of low fraction.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|